Roger J M Brüggemann Selected Research

posaconazole

3/2024	Personalized Antifungal Therapy Through Model-Informed Precision Dosing of Posaconazole.
7/2022	Posaconazole bioavailability of the solid oral tablet is reduced during severe intestinal mucositis.
1/2021	Posaconazole for prevention of invasive pulmonary aspergillosis in critically ill influenza patients (POSA-FLU): a randomised, open-label, proof-of-concept trial.
5/2020	Pharmacokinetics and Pharmacodynamics of Posaconazole.
2/2020	High-dose posaconazole for azole-resistant aspergillosis and other difficult-to-treat mould infections.
1/2020	Implications for IV posaconazole dosing in the era of obesity.
10/2017	Drug-drug interactions between triazole antifungal agents used to treat invasive aspergillosis and immunosuppressants metabolized by cytochrome P450 3A4.
11/2014	Understanding variability in posaconazole exposure using an integrated population pharmacokinetic analysis.
5/2014	Intrapulmonary posaconazole penetration at the infection site in an immunosuppressed murine model of invasive pulmonary aspergillosis receiving oral prophylactic regimens.
9/2013	Therapeutic drug monitoring of voriconazole and posaconazole for invasive aspergillosis.

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Roger J M Brüggemann Research Topics

Disease

16	Infections 01/2023 - 02/2010
13	Critical Illness (Critically Ill) 05/2024 - 02/2013
13	Aspergillosis 05/2020 - 12/2008
12	Mycoses (Diseases, Fungus) 03/2024 - 08/2008
11	Body Weight (Weight, Body) 05/2024 - 01/2013
7	Obesity 05/2024 - 06/2015
4	Invasive Fungal Infections 01/2020 - 06/2012
3	Neoplasms (Cancer) 12/2023 - 02/2018
3	COVID-19 11/2021 - 01/2020
3	Pulmonary Aspergillosis 11/2021 - 06/2012
3	Invasive Pulmonary Aspergillosis 01/2021 - 12/2008
3	Graft vs Host Disease (Graft-Versus-Host Disease) 01/2019 - 06/2012
2	Short Bowel Syndrome 01/2023 - 11/2021
2	Mucositis 07/2022 - 11/2014
2	Morbid Obesity 01/2022 - 10/2019
2	Sepsis (Septicemia) 10/2019 - 12/2012
2	Delirium 01/2018 - 11/2013
2	Chronic Granulomatous Disease 01/2017 - 09/2011
2	Diarrhea 11/2014 - 06/2012
2	Candidiasis (Moniliasis) 05/2013 - 11/2008
1	Overweight 11/2023
1	Intestinal Failure 01/2023
1	Disease Progression 11/2021
1	Respiratory Insufficiency (Respiratory Failure) 01/2021
1	Human Influenza (Influenza) 01/2021
1	Lung Diseases (Lung Disease) 01/2021
1	Mucormycosis 02/2020
1	Discitis 02/2020
1	Cysts 01/2020
1	Polycystic liver disease 01/2020
1	Ototoxicity 01/2020
1	Urinary Tract Infections (Urinary Tract Infection) 09/2019
1	Cystitis 01/2019
1	Coma (Comas) 01/2018
1	Drug-Related Side Effects and Adverse Reactions 09/2017
1	Invasive Candidiasis 01/2016
1	Hypoalbuminemia 01/2016
1	Burns 06/2015
1	Meningitis 05/2013
1	Pneumonia (Pneumonitis) 12/2012
1	Heart Failure 12/2012
1	Constipation 08/2011
1	Coinfection 11/2008

Drug/Important Bio-Agent (IBA)

15	posaconazole FDA Link 03/2024 - 05/2009
14	Voriconazole (Vfend)FDA LinkGeneric 02/2020 - 08/2008
7	AzolesIBA 02/2020 - 05/2009
5	isavuconazoleIBA 12/2023 - 05/2015
4	Ciprofloxacin (Cipro)FDA LinkGeneric 05/2024 - 10/2020
4	Floxacillin (Flucloxacillin)IBA 01/2023 - 01/2017
4	Gentamicins (Gentamicin)FDA LinkGeneric 11/2020 - 09/2017
4	AminoglycosidesIBA 01/2020 - 09/2017
4	TriazolesIBA 01/2020 - 08/2008
4	Caspofungin (Cancidas)FDA Link 01/2016 - 12/2012
3	Antifungal AgentsIBA 12/2023 - 01/2016
3	Vancomycin FDA LinkGeneric 11/2023 - 01/2020
3	Itraconazole (Sporanox)FDA LinkGeneric 01/2023 - 05/2009
3	Fluconazole (Zonal)FDA LinkGeneric 01/2023 - 11/2008
3	Anti-Bacterial Agents (Antibiotics)IBA 11/2021 - 10/2019
3	EchinocandinsIBA 01/2019 - 06/2015
3	Anidulafungin FDA Link 06/2015 - 01/2013
2	Tazobactam FDA LinkGeneric 09/2022 - 01/2022
2	Piperacillin FDA LinkGeneric 09/2022 - 01/2022
2	TabletsIBA 07/2022 - 05/2020
2	Biomarkers (Surrogate Marker)IBA 11/2021 - 01/2021
2	liposomal amphotericin B FDA Link 02/2020 - 01/2019
2	Nitrofurantoin (Macrodantin)FDA LinkGeneric 09/2019 - 01/2019
2	Micafungin (FK463)FDA Link 01/2019 - 06/2015
2	Haloperidol (Haldol)FDA LinkGeneric 01/2018 - 11/2013
1	Clindamycin (Cleocin)FDA LinkGeneric 01/2023
1	Anti-Infective Agents (Microbicides)IBA 01/2023
1	CitrullineIBA 07/2022
1	FluoroquinolonesIBA 01/2022
1	CreatinineIBA 11/2021
1	CytokinesIBA 01/2021
1	IA 4IBA 02/2020
1	1-dodecylpyridoxal (PLD)IBA 01/2020
1	Colistin (Coly-Mycin)FDA Link 01/2020
1	KininsIBA 01/2020
1	Everolimus FDA Link 02/2018
1	Tacrolimus (Prograf)FDA LinkGeneric 01/2018
1	Cytochrome P-450 CYP3AIBA 10/2017
1	Immunosuppressive Agents (Immunosuppressants)IBA 10/2017
1	ReninIBA 09/2017
1	Ceftazidime (Fortum)FDA LinkGeneric 09/2017
1	ProdrugsIBA 05/2015
1	Metoclopramide (Reglan)FDA LinkGeneric 11/2014
1	Proton Pump InhibitorsIBA 11/2014
1	Vincristine (Oncovin)FDA LinkGeneric 08/2011

Therapy/Procedure

17	Therapeutics 07/2022 - 11/2008
4	Bariatric Surgery 05/2024 - 10/2019
2	Salvage Therapy 02/2020 - 06/2012
2	Hematopoietic Stem Cell Transplantation 01/2019 - 10/2017
2	Extracorporeal Membrane Oxygenation 12/2012 - 12/2008
1	Intravenous Administration 01/2022
1	Organ Transplantation 02/2018
1	Artificial Respiration (Mechanical Ventilation) 01/2018
1	Length of Stay 01/2018
1	Device Removal (Removal, Device) 05/2013
1	Cerebrospinal Fluid Shunts 05/2013
1	Plasma Exchange 02/2013